Is PGT-A Right for You? Interpreting Results and the Cost-Benefit of Genetic Screening

Choosing to undergo Preimplantation Genetic Testing (PGT) is one of the most significant decisions you will make during your IVF journey. At Newlife IVF Greece, we believe that clarity is the antidote to anxiety. While the science behind genetic screening can feel complex, its goal is simple: to help you choose the embryo with the highest potential for a healthy pregnancy.

What exactly are we looking for?

PGT isn’t just one test; it’s a suite of tools tailored to your specific needs. The most common is PGT-A (Aneuploidy screening), which checks if an embryo has the correct number of chromosomes (46).

• Euploid: The "green light." These embryos have the correct chromosomal count.
• Aneuploid: These embryos have extra or missing chromosomes, which are the leading cause of implantation failure and miscarriage.
• Mosaic: A "yellow light" scenario where an embryo has a mix of normal and abnormal cells. Recent research, such as a 2024 study published in MDPI Diagnostics, indicates that many mosaic embryos can still lead to healthy, successful births. However, they have lower implantation and live birth rates compared to euploid embryos.

Eligibility: Who should consider PGT?

While PGT is an option for many, scientific guidelines-including those from the European Society of Human Reproduction and Embryology (ESHRE)-identify specific criteria where the clinical benefit is most pronounced. You may be highly eligible for PGT if you fall into these categories:

• Advanced maternal age (35+): As the risk of chromosomal aneuploidy increases significantly with age.
• Recurrent pregnancy loss: For those who have experienced two or more consecutive miscarriages.
• Repeated implantation failure: Following multiple unsuccessful IVF transfers.
• Known genetic carriers: Using PGT-M to prevent the transmission of specific single-gene disorders like Cystic Fibrosis.

The Cost-Benefit: Is it worth the investment?

The primary hurdle for many is the additional cost. However, the "value" of PGT is found in time and emotional well-being.

• Increased success per transfer: By selecting only euploid embryos, we significantly increase the pregnancy rate per individual transfer.
• Reduced miscarriage rates: Scientific data suggests that PGT-A can lower miscarriage rates by avoiding the transfer of chromosomally abnormal embryos.
• Faster "Time to Pregnancy": For many, PGT reduces the number of failed cycles and "blind" transfers, potentially saving the costs associated with multiple unsuccessful FET (Frozen Embryo Transfer) procedures.

At Newlife IVF Greece, our philosophy is rooted in individualized care. PGT is a powerful ally, but it is a choice that should be made based on your unique medical history, your number of available embryos, and your personal goals.

Our commitment is to provide you with the data you need to feel confident, not overwhelmed. Genetic screening is a bridge to a healthier future, and we are here to help you cross it.

Ready to demystify your options? Our expert medical team is here to provide a personalized assessment of whether PGT is the right step for your family. Contact Newlife IVF Greece today to schedule your free medical consultation.